This application note describes a method for the simultaneous determination of 26 carbamates and their metabolite residues in ginger by ultra-high performance liquid chromatography tandem mass spectrometry (UHPLC-MS/MS) based on the work published by He, et al . [1]. The ginger samples were initially extracted using acetonitrile, followed by cleanup using NH2 solid phase extraction (SPE) column. The samples were then enriched by nitrogen evaporation, redissolved in a mixture of acetonitrile:water (1:1, v:v), and analyzed by UHPLC-ESI-MS/MS. With matrix-matched standard calibration for quantitation, the method showed excellent linearity, with correlation coefficients of=0.99 for all compounds in the examined concentration range. The limits of detection and limits of quantitation were in the ranges of 0.0502.0 g/kg and 0.205.0 g/kg, respectively. At spiking levels of 10, 30, and 100 g/kg, the recoveries for all compounds ranged from 70.9119% with RSD of 1.011%. The method is simple, rapid, and sensitive, thus it can meet the requirements for the determination of carbamates and their metabolite residues in ginger. 安捷倫 1290 Infinity II 四元液相色譜系統(tǒng)