A new pyrrole building block is described, which allows for the regiospecific synthesis of 2,3,5-trisubstituted pyrroles and 2,3,4,5-tetrasubstituted pyrroles. Optimization studies are presented for the preparation of the pyrrole building block along with the evaluation of various cross-coup領(lǐng) conditions and cross-coup領(lǐng) agents. A short, formal synthesis of the natural products Polycitone A, Polycitone B, and Polycitrin A from the pyrrole building block is also described. Biotage 快速純化制備液相色譜 Flash Isolera one Biotage 快速純化制備液相色譜 Flash Isolera Prime Biotage 快速純化制備液相色譜 Flash Isolera LS