The TSQ Endura MS can perform screening and quantitation of 224 pesticides with 500 SRMs in peach matrix using a non-timed SRM MS method and a short LC run (<10 minutes) The ultra fast data acquisition rate of 500 SRM/s allowed us to improve productivity: significantly simplified method development, especially for large compound lists eliminate the need to set up a specific time windows for each compound Accommodate shifting retention times in different matrices shorten LC run time