Molecularly imprinted (MIP) and blank polymers with affinity for nonylphenolwere designed using computational model領(lǐng). Chromatographic tests demonstrated higher affinity of imprinted polymers towards the template nonylphenol as compared with blank polymers. The performance of both polymers in solid-phase extraction was however very similar. Both blank and imprinted polymers appeared to be suitable for the removal and preconcentration of nonylphenol from contaminated water samples with 99% efficiency of the recovery. The commercial resins PH(EC) (Biotage) and C18 (Varian) tested in the same conditions used for comparative purposes had recovery rate <84%. The polymer capacity for nonylphenolwas 231mgg?1 for blank and 228mgg?1 for MIP. The synthesised materials can have significance for sample pre-concentration and environmental analysis of this class of compounds.