Key Words Vanquish UHPLC System, Metoprolol, Metoprolol EP Impurity A, Metoprolol EP Impurity M, Metoprolol EP Impurity N, Corona Charged Aerosol Detector Goal To develop an impurity profi領 method for metoprolol and EP impurity A, which contain chromophores and two non-chromophoric impurities, using a hydrophilic interaction chromatography (HILIC) method coupled with charged aerosol detection (CAD). 賽默飛 Vanquish UHPLC超GX液相色譜系統(tǒng)