The integration of TappingMode imaging techniques into a fluid environment makes this a powerful tool for studying biological samples. When operating in fluid, a range of applications becomes available to the user. The acoustically driven fluid TappingMode is currently the most widely employed mode of AFM in biology, used for a variety of samples in several different areas of research. With this technique, researchers have successfully imaged a diverse range of samples without artifacts caused by drying or excessive force. Every sample has unique challenges and requirements but, with practice, there are few limits to the range of samples that can be investigated. DI Multimode V